PUblications

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Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX. A TBK1-independent primordial function of STING in lysosomal biogenesis. Molecular Cell. 2024 Sep 19.

          UPMC News: Double-Edged STING: Pitt Study Identifies New Pathway Involved in Aging

          BioArt: 谭小军团队揭示STING的原始功能在于溶酶体生成 

Bo Lv, Jinrui Xun, Jay Xiaojun Tan. STING-dependent ATG8ylation. 2024. Book Title: Atg8ylation And Its Manifestations, Edited By Vojo Deretic. ISBN:978-1-0364-0892-3. Cambridge Scholars Publishing

Jinrui Xun, Zhichao Zhang, Bo Lv, Defen Lu, Haoxiang Yang, Guijun Shang, Jay Xiaojun Tan. A conserved ion channel function of STING mediates noncanonical autophagy and cell death. EMBO Reports. published online. Jan 2, 2024.

                   Video synopsis!

                  Previous version before peer review: bioRxiv  2023:2023-08. 

Tan JX*, Finkel T. Lysosomes in senescence and aging. EMBO Reports. 2023: e57265. *Correspondence. 

Yang H, Tan JX. Lysosomal quality control: molecular mechanisms and therapeutic implications. 

Trends in Cell Biology. 2023.  DOI:https://doi.org/10.1016/j.tcb.2023.01.001 

Tan, JX, Finkel, T. A phosphoinositide signalling pathway mediates rapid lysosomal repair. Nature. (2022). https://doi.org/10.1038/s41586-022-05164-4 

         Highlights:   

                   A quick fix for lysosomes. Nat Struct Mol Biol 29, 955 (2022). 

                   Phosphoinositide signal for lysosomal membrane repair. Nat Rev Mol Cell Biol 23, 697 (2022).

                   PITTching in for lysosome repair. Dev Cell. 2022

                   The PITT pathway: Keeping lysosomes young. Clin Transl Med  12(10): e1097 (2022).

         UPMC news:  

                   PITT Pathway: Pitt Scientists Discover How Cells Repair Longevity-Promoting ‘Recycling System’ 

          Genetic Engineering & Biotechnology News:  

                   Longevity Depends on Prompt Repair of Lysosomal Breaches (genengnews.com) 

          学术经纬：今日《自然》：两位科学家首次揭示溶酶体修复的核心机制 

          BioArt： Nature | 溶酶体损伤修复的核心机制 

Tan X, Anderson RA. Keeping in touch with the ER network. Science.   2017;12;356(6338): 584-585. 

Tan X, Thapa N, Sun Y, Anderson RA. A kinase independent role for EGF   receptor in autophagy initiation. Cell. 2015;160(1-2):145-60. 

Tan X, Thapa N, Liao Y, Choi S, Anderson RA. PtdIns(4,5)P2  signaling regulates ATG14 and autophagy. PNAS. 2016;113(39):10896-901. doi: 10.1073/pnas.1523145113.

Tan X, Sun Y, Thapa N, Liao Y, Hedman AC, Anderson RA. LAPTM4B is a PtdIns(4,5)P2 effector that   regulates EGFR signaling, lysosomal sorting, and degradation. EMBO   J. 2015; 34(4):475-90. 

Tan JX, Finkel T. Autophagy goes nuclear. Nature Cell Biology. 2020;22(10):1159-61. 

 Tan JX, Finkel T. Mitochondria as intracellular signaling platforms in health and disease. Journal of Cell Biology.  2020;219(5): e202002179. 

Tan X, Sun L, Chen J, Chen ZJ. Detection of microbial infections through innate immune sensing of nucleic acids. Annual Review of Microbiology. 2018;72:447-78. 

Tan X, Lambert PF, Rapraeger AC, Anderson RA. Stress-induced EGFR trafficking:   mechanisms, functions, and therapeutic implications. Trends Cell Biol. 2016;26(5):352-66.   

Gui   X, Yang H, Li T, Tan X, Shi P, Du   F, Chen ZJ. Autophagy Induction via STING Trafficking Is a   Primordial Function of the cGAS Pathway. Nature. 2019;567(7747):262-266. 

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