PUblications

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JX Tan*, B Lv, J Li, T Li, F Du, X Chen, X Zhang, X-c Bai, ZJ Chen*. PtdIns (3, 5)P2 Is an Endogenous Ligand of STING in Innate Immune Signaling. Nature. 2026.  *Correspondence. 

• Highlight: STING signalling as a mediator between lipid metabolism and innate immunity. Nature Reviews Molecular Cell Biology (2026)
• Highlight: Glues that can STING: Lipids in innate immunity Mol Cell (2026)
• Highlight: Membrane lipids regulate the STING pathway and type I interferon responses. Cell Chemical Biology (2026)
• Pitt News: Understanding This Protein Can Illuminate Healthy Aging
• Chemical & Engineering News: Lipids are a dimmer switch for  inflammatory STING
• BioArt: STING的全新调控机制

J Li, JX Tan, ZJ Chen, X Zhang, X-c Bai. Regulation of STING activation by phosphoinositide and cholesterol. Nature. 2026. 

Yang H, Xun J, Li Y, Mondal A, Lv B, Watkins S, Shi L, Tan JX. LYVAC/PDZD8 is a lysosomal vacuolator. Science. 2025 Aug 21;389(6762):eadz0972. doi: 10.1126/science.adz0972 

• Highlight: A protein tunnel helps stressed lysosomes swell. Lippincott-Schwartz J. Science. 2025 Aug 21;389(6762):782-783. doi: 10.1126/science.aea5377.
• UPMC news: “Overinflated Balloons:” Study Reveals How Cellular Waste Disposal System Deals with Stress 
• BioArt: 溶酶体液泡化的核心机制 

Xun J, Tan JX. Lysosomal Repair in Health and Disease.  Journal of Cellular Physiology. 2025. 240 (5), e70044. Review article. 

Tan, J.X. Harnessing lysohormesis for healthy ageing. Nature Cell Biology, 2025. March 24: 1-4. Comment. 

Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX. A TBK1-independent primordial function of STING in lysosomal biogenesis. Molecular Cell. 2024 Sep 19.

• Highlight: TFEB links the cGAS-STING pathway to lysosome biogenesis
• UPMC News: Double-Edged STING: Pitt Study Identifies New Pathway Involved in Aging
• BioArt: STING的原始功能在于溶酶体生成 

Bo Lv, Jinrui Xun, Jay Xiaojun Tan. STING-dependent ATG8ylation. 2024. Book Title: Atg8ylation And Its Manifestations, Edited By Vojo Deretic. ISBN:978-1-0364-0892-3. Cambridge Scholars Publishing

Jinrui Xun, Zhichao Zhang, Bo Lv, Defen Lu, Haoxiang Yang, Guijun Shang, Jay Xiaojun Tan. A conserved ion channel function of STING mediates noncanonical autophagy and cell death. EMBO Reports. published online. Jan 2, 2024.

• Video synopsis!
• Highlight: STINGing organelle surface with acid
• Previous version before peer review: bioRxiv  2023:2023-08. 

Tan JX*, Finkel T. Lysosomes in senescence and aging. EMBO Reports. 2023: e57265. *Correspondence. 

Yang H, Tan JX. Lysosomal quality control: molecular mechanisms and therapeutic implications. Trends in Cell Biology. 2023.  DOI:https://doi.org/10.1016/j.tcb.2023.01.001 

Tan, JX*, Finkel, T*. A phosphoinositide signalling pathway mediates rapid lysosomal repair. Nature. (2022). https://doi.org/10.1038/s41586-022-05164-4 

• Highlight: A quick fix for lysosomes. Nat Struct Mol Biol 29, 955 (2022). 
• Highlight: Phosphoinositide signal for lysosomal membrane repair. Nat Rev Mol Cell Biol 23, 697 (2022).
• Highlight: PITTching in for lysosome repair. Dev Cell. 2022
• Highlight: The PITT pathway: Keeping lysosomes young. Clin Transl Med  12(10): e1097 (2022).
• UPMC news: PITT Pathway: Pitt Scientists Discover How Cells Repair Longevity-Promoting ‘Recycling System’ 
• Genetic Engineering & Biotechnology News: Longevity Depends on Prompt Repair of Lysosomal Breaches (genengnews.com) 
• 学术经纬：今日《自然》：两位科学家首次揭示溶酶体修复的核心机制 
• BioArt： Nature | 溶酶体损伤修复的核心机制 

Tan X, Anderson RA. Keeping in touch with the ER network. Science.   2017;12;356(6338): 584-585. 

Tan X, Thapa N, Sun Y, Anderson RA. A kinase independent role for EGF   receptor in autophagy initiation. Cell. 2015;160(1-2):145-60. 

Tan X, Thapa N, Liao Y, Choi S, Anderson RA. PtdIns(4,5)P2  signaling regulates ATG14 and autophagy. PNAS. 2016;113(39):10896-901. doi: 10.1073/pnas.1523145113.

Tan X, Sun Y, Thapa N, Liao Y, Hedman AC, Anderson RA. LAPTM4B is a PtdIns(4,5)P2 effector that   regulates EGFR signaling, lysosomal sorting, and degradation. EMBO   J. 2015; 34(4):475-90. 

Tan JX, Finkel T. Autophagy goes nuclear. Nature Cell Biology. 2020;22(10):1159-61. 

 Tan JX, Finkel T. Mitochondria as intracellular signaling platforms in health and disease. Journal of Cell Biology.  2020;219(5): e202002179. 

Tan X, Sun L, Chen J, Chen ZJ. Detection of microbial infections through innate immune sensing of nucleic acids. Annual Review of Microbiology. 2018;72:447-78. 

Tan X, Lambert PF, Rapraeger AC, Anderson RA. Stress-induced EGFR trafficking:   mechanisms, functions, and therapeutic implications. Trends Cell Biol. 2016;26(5):352-66.   

Gui   X, Yang H, Li T, Tan X, Shi P, Du   F, Chen ZJ. Autophagy Induction via STING Trafficking Is a   Primordial Function of the cGAS Pathway. Nature. 2019;567(7747):262-266. 

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