Jay Xiaojun Tan, PhD

Assistant Professor

Aging Institute

Department of Cell Biology

University of Pittsburgh School of Medicine/UPMC

564 Bridgeside Point I Building

100 Technology Drive

Pittsburgh, PA 15219

Email: Jay.Tan at Pitt.edu


 ACADEMIC TRAINING 

2019 - 2022

  Research Assistant Professor, Aging Institute & Department of Cell   Biology

 University of Pittsburgh School of Medicine, USA


2016 - 2019 

  Postdoctoral Fellow, Department of Molecular Biology

 University of Texas Southwestern Medical Center, USA


2009 - 2015
 Ph.D. in Molecular & Cellular Pharmacology - Dec 2015

 University of Wisconsin-Madison, USA


2005 - 2009

  B.S. with Honors - May 2009
Nanjing University, Nanjing, Jiangsu, China


     

SELECTIVE AWARDS 

2023-2028 NIGMS Maximizing Investigators' Research Award (MIRA) (R35)

2022-2023 NIH/NIA   K01 Mentored Research Scientist Development Award 

2021 UPMC Competitive Medical Research Fund (CMRF) Award

2016-2019 Cancer Research Institute Irvington Postdoctoral Fellowship

2016 Award for Exceptional Contribution to the Phospholipid Signaling Field, FASEB Science Research Conference

2012-2014 Howard Hughes Medical Institute (HHMI) Predoctoral Fellowship


Jay's interest in science began during his undergraduate research at Nanjing University, where he studied biochemistry, cell biology, and pharmacology. During his Ph.D. as a Howard Hughes Medical Institute (HHMI) predoctoral fellow at the University of Wisconsin-Madison, Jay studied stress-induced membrane trafficking and made several discoveries, including the non-canonical role of EGFR in autophagy initiation and lipid regulation of receptor trafficking. Supported by Cancer Research Institute (CRI) Irvington Postdoctoral Fellowship, his postdoctoral work at UT Southwestern focused on lipid regulation of the cGAS/STING innate immune pathway and the role for STING in non-canonical autophagy. Jay's research experience in lysosomal degradation, stress response, autophagy, and innate immunity led him to pursue a career in aging research, which he currently conducts as a faculty member at the University of Pittsburgh School of Medicine. He recently discovered the PITT pathway for rapid lysosomal repair, which has broad implications for aging and age-related diseases. Jay received his NIA K01 career development award in January 2022 and started his independent lab in July of the same year in the Aging Institute and Department of Cell Biology at the University of Pittsburgh.  

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