09/07/2023
Jay gave a talk at the Wellcome Connecting Science Conference -
Trafficking Pathways in Neurodegeneration, 6–8 September 2023, Wellcome Genome Campus, UK
09/01/2023
The Tan lab received a MIRA R35 award from NIGMS. Great news for the lab!
08/28/2023
We bioRxiv'ed a manuscript - A conserved ion channel function of STING in non-canonical autophagy and cell death. Congratulations to all the co-authors!
08/21/2023
Awishi Mondal joined us as a rotation student. Awishi had her B.S. in Zoology and M.S. in Biophysics and Molecular Biology. She is interested in protein-protein interactions, cellular quality control, and drug discovery. Welcome Awishi!
05/04/2023
The Tan lab attended Local Traffic 2023 - the 22nd annual Pittsburgh Symposium on Membrane Traffic.
04/17/2023
Haoxiang presented his work at the Aging Institute Research in Progress Seminar. Well done, Haoxiang!
02/15/2023
Nailah A. Simmons joined our lab as an undergraduate researcher. Nailah is currently a sophomore student at Pitt. As a public health major on the pre-med track, she is especially interested in pinpointing and analyzing risk factors that contribute to disease and aging. Welcome, Nailah!
01/15/2023
Dr. Bo Lyu joined our lab as a senior postdoctoral researcher. Dr. Lyu holds a Ph.D. in genetics and has extensive research experience in molecular and cell biology. Welcome, Dr. Lyu!
01/13/2023
Our first review article is accepted by Trends in Cell Biology. Cheers!
Yang H, Tan JX. Lysosomal quality control: molecular mechanisms and therapeutic implications. DOI:https://doi.org/10.1016/j.tcb.2023.01.001
01/11/2023
The Tan lab joined VMI/Aging Institute holiday party at Sienna Mercato. Cheers!
11/18/2022
Jinrui (Jeffrey) Xun joined our lab as a visiting scholar. He is an MD candidate from Xiangya Medical School. He is interested in cellular stress responses that could be potentially targeted for patients' health. Welcome, Jeffrey!
09/07/2022
Our recent work on lysosomal repair is published online today at Nature.
In this study, we identified the PITT (phosphoinositide-initiated membrane tethering and lipid transport) pathway as an essential mechanism for rapid lysosomal repair. Congratulations!
Research highlights:
A quick fix for lysosomes. Nat Struct Mol Biol 29, 955 (2022).
Phosphoinositide signal for lysosomal membrane repair. Nat Rev Mol Cell Biol 23, 697 (2022).
PITTching in for lysosome repair. Dev Cell. 2022
The PITT pathway: Keeping lysosomes young. Clin Transl Med 12(10): e1097 (2022).
UPMC news:
PITT Pathway: Pitt Scientists Discover How Cells Repair Longevity-Promoting ‘Recycling System’
Genetic Engineering & Biotechnology News:
Longevity Depends on Prompt Repair of Lysosomal Breaches (genengnews.com)
学术经纬：今日《自然》：两位科学家首次揭示溶酶体修复的核心机制
BioArt： Nature | 溶酶体损伤修复的核心机制
08/17/2022
Jay was invited to present at ASBMB Lipid Research Division Seminar Series. Looking forward to the seminar at noon on Aug 31, 2022.
08/12/2022
Haoxiang Yang joined our lab as a research assistant. Haoxiang has a strong background in computer science. He is learning aging biology and pursuing a future career applying his CS expertise to aging research. Welcome, Haoxiang!
07/22/2022
Our new lab is up and running!
07/19/2022
Jay was invited for a talk at the 2022 FASEB phospholipid meeting in Jupiter, FL. Congratulations!
07/01/2022
The Tan lab is official today in Aging Institute and Department of Cell Biology at University of Pittsburgh!