09/19/2024
Congratulations to Bo Lv & coauthors for publishing a paper at MolecularCell !
We uncovered a primordial role of the cGAS-STING pathway in lysosomal biogenesis & stress clearance, revealing its ancient function predating type I interferons.
Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX. A TBK1-independent primordial function of STING in lysosomal biogenesis. Molecular Cell. 2024 Sep 19.
UPMC News: Double-Edged STING: Pitt Study Identifies New Pathway Involved in Aging
BioArt: STING的原始功能在于溶酶体生成
Here is a link for free PDF: https://authors.elsevier.com/a/1joCM3vVUPRmvu
09/01/2024
Dr. Xiaojie Yu joined us today as a postdoctoral researcher. Dr. Yu received her Ph.D. in life science at Hong Kong University of Science and Technology. She is an expert in high-resolution imaging, neuroscience, molecular biology, and biochemistry. Welcome, Dr. Yu!
8/21/2024
Bo and Jeff published a book chapter. Congratulations!
Bo Lv, Jinrui Xun, Jay Xiaojun Tan. STING-dependent ATG8ylation. 2024. Book Title: Atg8ylation And Its Manifestations, Edited by Vojo Deretic. ISBN:978-1-0364-0892-3. Cambridge Scholars Publishing
6/17/2024
Anna S. Apetrei-Pandrea joined our lab as a 2024 Hillman Academy Scholar. Anna will develop a proximity labeling system to explore new pathways in innate immunity. Welcome, Anna!
5/2/2024
The whole lab attended the 1st Annual Pittburgh Cell Biology Conference at FRICK FINE ARTS CENTER. Congratulations to Haoxiang for delivering a wonderful talk!
4/15/2024
Dr. Bo Lyu presented his work at the 17th UPPDA Postdoctoral Research Symposium! Well done Bo!
04/01/2024
Dr. Fangling Tian joined our lab as a postdoctoral researcher. Dr. Tian received her Ph.D. in Microbiology from Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, University of Chinese Academy of Sciences, and has extensive research experience in molecular biology, cell biology, and virology. Welcome, Dr. Tian!
02/22/2024
Zhenjie Yi joined our lab as an MD student. He is from Xiangya Medical School at Central South University. His interest lies in exploring cellular stress response pathways that may hold promise for benefiting patients undergoing brain surgery. Welcome, Zhenjie!
01/02/2024
The peer-reviewed version of the "STING channel" work is online today at EMBO Reports. Congratulations to Jeff and Bo!
01/02/2024
Anuj Peri joined our lab as an undergraduate researcher. Anuj is currently a freshman at the University of Pittsburgh’s Frederick Honors College majoring in molecular biology. He is interested in molecular genetics and cell biology and their wider impacts on human health, specifically with tackling aging. His goal is to actively participate in research on lysosomal quality control and to acquire insights into treating lysosomal-related diseases throughout his undergraduate career. Welcome, Anuj!
01/02/2024
Rae Yang joined our lab as an undergraduate researcher. Rae is currently a first-year college student at the University of Pittsburgh, majoring in Biological Sciences and minoring in Music on the pre-medical track. Rae is intrigued by the correlation between organelle stress and human illnesses, alongside her focus on lysosomal quality control in aging. She's keen to delve deeper into understanding how lysosome dysfunction affects cellular balance and exploring strategies for prompt lysosomal repair that could lead to innovative treatments for neurodegenerative disorders. Welcome, Rae!
01/02/2024
Jenny Cheng joined our lab as an undergraduate researcher. Jenny is currently a junior at the University of Pittsburgh majoring in Molecular Biology and minoring in Chemistry and Chinese. Jenny is interested in how organelle stress and damage could be a risk factor in aging and also diseases, and would like to devote into the investigation in extending lifespan by stimulating cellular stress response pathways. With these research experience, Jenny aims to develop an exciting research career. Welcome, Jenny!
11/01/2023
The whole lab attended the Aging Research Day at the University Club.
Congratulations to Jeff and Bo who received a poster award for the "STING channel" work!
09/22/2023
Our review article "Lysosomes in senescence and aging" is accepted by EMBO Reports. Cheers!
09/22/2023
The whole lab attended the annual Cell Biology retreat at Pittsburgh Zoo and Aquarium. Congratulations to Haoxiang and Jeff for their poster presentations!
09/07/2023
Jay gave a talk at the Wellcome Connecting Science Conference -
Trafficking Pathways in Neurodegeneration, 6–8 September 2023, Wellcome Genome Campus, UK
09/01/2023
The Tan lab received a MIRA R35 award from NIGMS. Great news for the lab!
08/28/2023
We bioRxiv'ed a manuscript - A conserved ion channel function of STING in non-canonical autophagy and cell death. Congratulations to all the co-authors!
08/21/2023
Awishi Mondal joined us as a PhD student. Awishi had her B.S. in Zoology and M.S. in Biophysics and Molecular Biology. She is interested in protein-protein interactions, cellular quality control, and drug discovery. Welcome Awishi!
05/04/2023
The Tan lab attended Local Traffic 2023 - the 22nd annual Pittsburgh Symposium on Membrane Traffic.
04/17/2023
Haoxiang presented his work at the Aging Institute Research in Progress Seminar. Well done, Haoxiang!
01/15/2023
Dr. Bo Lyu joined our lab as a senior postdoctoral researcher. Dr. Lyu holds a Ph.D. in genetics and has extensive research experience in molecular and cell biology. Welcome, Dr. Lyu!
01/13/2023
Our first review article is accepted by Trends in Cell Biology. Cheers!
Yang H, Tan JX. Lysosomal quality control: molecular mechanisms and therapeutic implications. DOI:https://doi.org/10.1016/j.tcb.2023.01.001
01/11/2023
The Tan lab joined VMI/Aging Institute holiday party at Sienna Mercato. Cheers!
11/18/2022
Jinrui (Jeffrey) Xun joined our lab as a visiting scholar. He is an MD candidate from Xiangya Medical School. He is interested in cellular stress responses that could be potentially targeted for patients' health. Welcome, Jeffrey!
09/07/2022
Our recent work on lysosomal repair is published online today at Nature.
In this study, we identified the PITT (phosphoinositide-initiated membrane tethering and lipid transport) pathway as an essential mechanism for rapid lysosomal repair. Congratulations!
Research highlights:
A quick fix for lysosomes. Nat Struct Mol Biol 29, 955 (2022).
Phosphoinositide signal for lysosomal membrane repair. Nat Rev Mol Cell Biol 23, 697 (2022).
PITTching in for lysosome repair. Dev Cell. 2022
The PITT pathway: Keeping lysosomes young. Clin Transl Med 12(10): e1097 (2022).
UPMC news:
PITT Pathway: Pitt Scientists Discover How Cells Repair Longevity-Promoting ‘Recycling System’
Genetic Engineering & Biotechnology News:
Longevity Depends on Prompt Repair of Lysosomal Breaches (genengnews.com)
学术经纬：今日《自然》：两位科学家首次揭示溶酶体修复的核心机制
BioArt： Nature | 溶酶体损伤修复的核心机制
08/17/2022
Jay was invited to present at ASBMB Lipid Research Division Seminar Series. Looking forward to the seminar at noon on Aug 31, 2022.
08/12/2022
Haoxiang Yang joined our lab as a research assistant. Haoxiang has a strong background in computer science. He is learning aging biology and pursuing a future career applying his CS expertise to aging research. Welcome, Haoxiang!
07/22/2022
Our new lab is up and running!
07/19/2022
Jay was invited for a talk at the 2022 FASEB phospholipid meeting in Jupiter, FL. Congratulations!
07/01/2022
The Tan lab is official today in Aging Institute and Department of Cell Biology at University of Pittsburgh!